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That said, the clearest human evidence so far is a small pilot where three months of B12 brought deficient older adults strength up to match non-deficient peers promising, but larger trials are the next step, especially on whether B12 supplementation helps people who arent prone to deficiencies

Maintaining results after GLP-1 typically involves prioritizing protein intake, engaging in regular strength training, supporting sleep quality, managing stress, and scheduling periodic monitoring with your provider

At the end of that trial, the researchers re-randomized people taking both drugs to switch to either orforglipron or a placebo

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