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Lancet 389 , 834845 (2017)

Plasma homocysteine and cardiovascular disease mortality

Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders

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However, despite the clear physical and physiological differences between women and menand their evident impact on disease development and comorbiditysex differences in transcriptional similarities between diseases have not been systematically investigated