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Transcription factor Egr-1 activates collagen expression in immortalized fibroblasts or fibrosarcoma cells

No changes in IGF-1

Sikiri & Hahm et al

What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date

Youll want to evaluate the ideal dosage timing to achieve the best results