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Preclinical studies suggest the presence of these receptors in bone tissue and cells involved in bone remodeling, though this remains an area of ongoing investigation in humans

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A 2018 review in the International Journal of Molecular Sciences analyzed available gene expression data and found that GHK-Cu at clinically relevant concentrations affected the expression of approximately 31.2% of human genes [2]

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This places them at elevated risk for B12 deficiency, and standard oral supplementation may not provide adequate absorption