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Semaglutide 2.4 mg was associated with a 20% reduction in major adverse cardiovascular events compared with placebo
The scenarios where injectable GLP-1s are clearly superior: A1C above 9.0% (need for maximum efficacy) Established cardiovascular disease (need for proven MACE reduction) Primary goal is weight loss (need for higher semaglutide exposure) Difficulty with medication adherence (weekly is easier than daily for many patients) Unpredictable morning schedule (can't guarantee empty stomach timing) The decision is patient-specific
Think of your weight loss journey as building a house
The other problem is, patients often cant get B12 shots anywhere else
