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Although we were unable to assess blood drugs levels in the TriNetX database, the consistent reduction in MAKEs observed in steroid, tacrolimus and cyclosporine subgroups provides indirect reassurance of the safety of GLP-1 RAs in KRTs and regardless of the specific immunosuppressive regimen

This enzyme can reduce oxidized glutathione (GSSG) to reduced glutathione (GSH) in an NADPH-dependent manner

However, ultrasound should be considered for patients with: Suggestive symptoms or examination findings Significantly elevated liver enzymes History of previous biliary symptoms Ongoing Monitoring during treatment includes: Regular clinical follow-up (typically every 412 weeks initially) Patient education about warning symptoms requiring urgent evaluation Periodic liver function monitoring if clinically indicated Gradual dose titration to moderate weight loss velocity when feasible Red Flag Symptoms requiring immediate medical attention include: Severe, persistent right upper quadrant or epigastric pain Fever with abdominal pain Jaundice (yellowing of skin or eyes) Dark urine or pale stools Persistent nausea and vomiting Patients experiencing these symptoms should seek urgent medical evaluation

After matching, the study included 162,253 case and control patients

Thyroid function testing may be appropriate, as hypothyroidism can cause muscle symptoms and may coexist with metabolic conditions

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