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In glioma cells, the constant cation current required for cell growth and migration was shown to be mediated by ASIC1a (Rooj et al., 2012)

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NICE has not issued guidance as no marketing authorisation has been granted

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On procedures, the FDA found that Novo Nordisk's internal protocol allowed adverse drug experiences to be rejected if the reporter believed events were unrelated to the drug directly contradicting FDA regulations requiring all serious and unexpected events to be reported regardless of suspected causality