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High protein intake is especially important because it provides the greatest satiety per calorie, partially compensating for the loss of GLP-1 mediated appetite suppression

When evaluating gastrointestinal studies, researchers should consider the injury model, controlled exposure design, timing of observation, lesion-scoring method, vascular endpoints, inflammatory markers, and whether pathway inhibitors were included

Effects in mice and rats do not reliably predict effects in humans, and animal dosing does not translate directly