[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy
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Unlike metformin, which has a well-documented association with reduced vitamin B12 absorption, tirzepatide has not demonstrated a similar pharmacological mechanism that would directly interfere with B12 metabolism or absorption in the terminal ileum
Among these regulators, small regulatory peptides, often described under an umbrella term matrikines, attract particular interest [ 15 ]
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