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Gut-brain axis and the spread of -Synuclein pathology: vagal highway or dead end
By promoting the conversion of acetyl-CoA to acetylcarnitine, carnitine reduces the ratio of acetyl-CoA/CoA, thereby reducing the activity of PDH kinase and restoring the activity of PDH, allowing more pyruvate to enter the mitochondria for oxidation to produce energy [288]
Research suggests this may be related to reduced oxidative stress, inflammation, and abnormal tissue signaling
Although the underlying contributors to these differences cannot be determined from observational data, potential factors may include variation in baseline clinical characteristics, access to care, treatment persistence, dose escalation, social determinants of health, and unmeasured biological heterogeneity
[PMID: 8504638] PubMed record related to this compound for laboratory literature review
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