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Oral cyanocobalamin supplementation (typically 50150 micrograms daily) represents an appropriate option for patients with dietary deficiency without intrinsic factor deficiency or malabsorption issues
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When B12 levels are low, red blood cells can become large and inefficient, contributing to fatigue and weakness
[57] Several serious, even life-threatening diseases cause elevated serum haptocorrin, measured as abnormally high serum vitamin B 12 , while at the same time potentially manifesting as a symptomatic vitamin deficiency because of insufficient vitamin bound to transcobalamin II which transfers the vitamin to cells