Those drugs are complex peptides that must be injected because they cannot survive the digestive system intact, and they cannot penetrate the skin in meaningful amounts either (6)
Either way, the mechanistic worry I raised in June is resolved
Several factors make RUO GLP-1 sales especially risky: The compounds are identical to approved drugs Demand is driven by widespread consumer and clinical use, not niche research Sales volumes often exceed what would be expected for legitimate laboratory research Buyers frequently include wellness clinics, telehealth providers, and resellers rather than research institutions When these facts are present, RUO disclaimers carry little weight
For arm or thigh injections: These sites typically have thinner subcutaneous layers than the abdomen, so a pinch may be warranted even if you wouldnt need one for stomach injections
Clinical trials evaluating tirzepatide safety, including the SURPASS and SURMOUNT trial programs, did not identify genitourinary fungal infections as a significant concern compared to placebo or active comparators
Frontiers in molecular neuroscience