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This binding switches 15LO1s preferred substrate from free arachidonic acid to arachidonic acid conjugated to PE, which generates ferroptotic lipids, including the hydroperoxy-phospholipid 15-hydroperoxy-eicosatetraenoic acidPE (15-HpETE-PE) (6, 7, 10, 13)

Genes Dkk4 and Smad6 related to the Wnt/-catenin signaling pathway were differentially expressed in both anwuligan-treated mouse skin tissues and HFSCs

[PMID: 15670627] PubMed record related to this compound for laboratory literature review

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Huang ZR, Lin YK, Fang JY (2009) Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology

Enzymatic treatment included 40U DNase-I, 1000 g/ml Amylase, 500 g/ml Proteinase K and a combination of 40U DNase-I + 4 g/mL amikacin or 40U DNase-I + 30 mM GSH