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One intra-articular (into the knee joint) case series of 12 people with chronic knee pain found 7 out of 12 had major pain relief lasting over 6 months

Bedtime dosing better matches the bodys natural GH pulse during deep sleep and improves adherence

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Anesth Analg 120(2):320328 de Oliveira L, Fraga DB, De Luca RD, Canever L, Ghedim FV, Matos MP, Streck EL, Quevedo J, Zugno AI (2011) Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine

If an adverse effect, or even the inconvenience, of a particular therapy outweighs the benefits for the patient, then it might not be worthwhile to include it in a management strategy