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52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)

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Posted October 19, 2023

Additionally, limited research exists on the combined use of GLP-1 receptor agonists and cannabis, meaning potential interactions or adverse outcomes may not yet be fully characterised

A letter of medical necessity along with an HSA receipt are available through the patient portal

Firstly, hyperglycemia promotes local ANG II production in cardiomyocytes stimulating intracellular chymase and/or internalized prorenin, leading to diabetic cardiomyopathy