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Mixing is carried out under controlled conditions
It inhibits the NF-B and MAPK signaling pathways by activating the SIRT1 deacetylase, reduces ROS production, and delays chondrocyte apoptosis (48)
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Researchers designed it specifically to optimize certain properties, enhanced stability, targeted follicle activity, and reduced interference with other biological processes
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For example, 2D cultures only allow interactions with neighboring cells and the formation of cell-ECM adhesions on the substrate side in the horizontal plane, whereas in 3D culture, cells are capable of forming adhesions on all sides in a dynamic way [239]
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