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Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)
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This is also why GHK-Cu appears frequently in longevity-adjacent research alongside other compounds studied for age-related cellular changes, since a quantifiable, age-correlated decline gives researchers a concrete variable to test against rather than a purely theoretical one
Excessive muscle loss can: A 2023 study published in Obesity found that up to 39% of the weight lost on semaglutide came from lean body massunderscoring the need for protective strategies
Some people face higher risks of stomach slowing from these medications
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