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If a patient with G6PD deficiency were to develop methemoglobinemia (one of the few scenarios where MB might otherwise be indicated), alternative treatments (such as high-dose vitamin C or exchange transfusion) should be employed instead of MB

In contrast, many studies on metabolic modulators, herbal formulations, or supplements have been constrained by small sample sizes, short durations, and reliance on surrogate endpoints such as NT-proBNP reduction or improvements in left ventricular ejection fraction

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