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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface
In accordance with a further aspect, an effective daily amount of S-acetyl-glutathione (SAG) may be orally administered to an individual in need thereof in one to four doses in the form of 2 to 10 acid-resistant capsules
Trends Endocrinol Metab 19(1):1724
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