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Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule , this ultra-low molecular weight version is a controversial ingredient

10.1007/s00018-022-04505-w 55

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doi: 10.3109/00365519609088799 73

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Although the pathogenesis of IBD remains still unclear, their development is considered as the result of genetic, environmental, gut microbiota, intestinal permeability, and immune response factors [36]