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In PD, the accumulation of S in the SNpc leads to a downregulation of Sirt3 expression (Reczek and Chandel, 2015)

Kidney disease is another factor to consider, as dehydration from side effects could worsen kidney function

Their main side effects are usually nausea and vomiting. In TRIUMPH-2, up to 11.6 percent of participants using retatrutide stopped the drug before the end of the trial due to side effects, compared with 4.9 percent of the placebo group