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According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)

Apr 2021;27(1):8-14

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Open 7 , e2421305 (2024)

Compared with healthy controls, these individuals had higher levels of glutamate and dopamine in the basal ganglia and lower levels of glutamate, GABA, and dopamine in cortical regions, especially in the frontal cortex