Evolving theories of the pathophysiology of major depression have implicated overactivation of inflammatory pathways, ill-defined changes in glutamate metabolism, and disconnection of cortical and subcortical components of a neural reward circuit
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Upadhyaya CP, Venkatesh J, Gururani MA, Asnin L, Sharma K, Ajappala H, Park SW (2011) Transgenic potato overproducing L-ascorbic acid resisted an increase in methylglyoxal under salinity stress via maintaining higher reduced glutathione level and glyoxalase enzyme activity