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4-hydroxynonenal self-limits Fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas

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Furthermore, ACSL4-mediated esterification of PUFAs into peroxidation-vulnerable membrane domains establishes a self-reinforcing pathway, with elevated ACSL4 expression in stroke, AD, and PD intensifying lipid oxidative damage (Zheng et al., 2024), collectively forming an iron-dependent oxidative injury axis

MAFLD is also referred to as metabolic dysfunction-associated steatotic liver disease, MASLD