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Wegovy, specifically approved for obesity management, follows a titration ladder from 0.25 mg weekly to a maximum of 2.4 mg
Warnings For use by healthy adults only
GLP-1R action on neuroprotection GLP-1R analogs have neuroprotective and anti-inflammatory properties, which may be contributing the beneficial effects on energy metabolism (reviewed in Holscher, 2014)
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Theres biological rationale that GLP-1 RAs may have neuroprotective effects (they reduce inflammation, improve insulin signaling in the brain, etc.)
Lehrke M, Broedl UC, Biller-Friedmann IM, et al
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