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UA activates the inflammatory response of tissue-intrinsic cells indirectly affecting immune cells MSU crystals activate the TLR4/NF-B/NLRP3 signaling pathway in human umbilical vein endothelial cells (HUVECs), leading to the secretion of intercellular cell adhesion molecule-1 (ICAM-1), IL-1, IL-6, and vascular cellular adhesion molecule-1 (VCAM-1)
It becomes readily available for the body to use
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doi:10.1016/j.crfs.2023.100599
6C, F, G, I)
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