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Studies have shown that the gut microbiota not only directly affects the production of glucocorticoids and immune mediators, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and IL-6, but also further stimulates HPA axis activity through these mediators (112)

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T., Cummings, C., and Gargus, J

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The mRNA expression data was available from 501 thyroid cancer samples and 59 healthy thyroid controls