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doi: 10.1016/S0140-6736(18)32261-X 13 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

[5] The primary contraindication for hydroxocobalamin injection is a known hypersensitivity to hydroxocobalamin, cobalt, or any component of the formulation

The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect

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Risks can include diabetes, hypertension (high blood pressure), high cholesterol, sleep apnea, heart attack, stroke and even risks of early death