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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

doi:10.1038/ejcn.2014.281

The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are nuclear receptors that regulate genes involved in bilirubin and bile acid detoxification

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