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To qualify for a GLP-1 prescribed for weight loss, you need a BMI of 30 or above, or a BMI of 27 or above with at least one weight-related comorbidity, and no contraindications in your medical history
Changes in nutrition People who lose weight rapidly sometimes consume less calcium, protein or vitamin Dnutrients essential for maintaining bone strength
Fat holds food in the stomach longer
Targeting both GLP-1 and insulin secretion with a SSTR5 antagonist could perhaps be an advantage in the treatment of hyperglycemia in humans
Phase 2 trials already showed up to 24.2% body weight reduction at 48 weeks, making it the most potent weight loss compound in clinical development
However, the modest effect does not negate the potential value of these drugs, especially for conditions where few effective treatment options exist, for example, dementia, Al-Aly said
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