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Spinocerebellar ataxias (SCAs) SCAs are a group of rare autosomal dominant neurodegenerative diseases characterized by gait difficulty, loss of hand dexterity, dysarthria, and cognitive decline

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It is thought that the elevation of homocysteine levels might be partly due to vitamin B 12 deficiency in individuals over 60 years of age

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However, therapeutic doses for treating deficiency and associated nerve damage are substantially higher