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Clinical and in vitro studies demonstrate that GHK-Cu significantly increases the production of collagen types I and III, elastin, and glycosaminoglycanskey structural components responsible for skin firmness and elasticity (Maquart et al., 1988

Cagrilintide vs AOD 9604 Mechanism: Cagrilintide: Amylin receptor agonist (appetite/satiety) AOD 9604: HGH fragment (fat metabolism) Completely different Weight loss: Cagrilintide: 10-12% body weight AOD 9604: 5-8% body weight (less robust data) Cagrilintide superior Clinical evidence: Cagrilintide: Extensive Phase 2/3 trials AOD 9604: Limited clinical data Cagrilintide better studied Side effects: Cagrilintide: GI effects common AOD 9604: Minimal side effects AOD 9604 better tolerated Combination potential: Could theoretically combine (different mechanisms) No clinical data on combination Cagrilintide + semaglutide better established Verdict: Cagrilintide more powerful, better evidence

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doi: 10.1016/j.neuint.2012.08.017 330 SchmuklerE.SolomonS.SimonovitchS.GoldshmitY.WolfsonE.MichaelsonD

Understanding these potential mechanisms helps clinicians and patients identify strategies to minimise discomfort whilst maintaining adequate B12 intake