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Every dose below comes from the Novo Nordisk trial programme
Because the cysteine thiol oxidises to the disulfide GSSG on air exposure, keep stopper-open time and headspace to a minimum and avoid alkaline solvents, which increase thiolate character and accelerate oxidation
Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below
Its also advised against for individuals with active or suspected cancer or those with Wilsons disease, a rare genetic disorder related to copper metabolism
Detmar, M
Peer reviewer reports are available
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