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2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

For example, a group of 58 women with cervical dysplasia seen on colposcopy (CIN1), ages 18 to 58, were enrolled in a randomized, double-blind, placebo controlled study, and divided into two groups

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O., Haneli, R