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The chances of developing altitude sickness are lower if you go to a higher altitude gradually, but this isnt always possible when you take a plane trip to Denver, for instance

10.1073/pnas.0504423102 170 WangJ

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Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Effects of Shulikang Capsule on heart rate of young men exposed rapidly to high altitude