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Additional work has established that late-night dinner consumption is associated with increased total calorie intake, which may explain why participants with both behaviors (breakfast skipping and late-night dinner eating) showed the highest disease severity, representing a double metabolic hit of circadian disruption plus evening caloric excess

Focus on healthy fats from sources like avocado, nuts, and olive oil in small controlled portions

Stem Cells Transl Med

In spite of promising data, issues remain about standardizing its active components, pharmacokinetics, and lack of large scale human trials

Early access may require special authorization, documented treatment failure on alternatives, or appeal processes

This effect is most pronounced during early treatment and may diminish with continued therapy