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The SURMOUNT-4 trial with tirzepatide showed that participants who continued the medication lost an additional 5.5% of their body weight, while those who switched to a placebo regained 14%

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The thigh is one of the three recommended injection sitesalong with the abdomen and upper armbecause it offers good accessibility and a thick layer of subcutaneous tissue that absorbs medication reliably

Atherosclerosis-model mice treated with exendin-4, another GLP-1RA, also demonstrated reduced circulating levels of monocyte chemoattractant protein-1, C-X-C motif chemokine ligand-1 (CXCL-1), and ultimately neutrophil recruitment (Wang et al., 2014)

First isolated in 1977 from rabbit cerebral venous blood, DSIP is classified as amphiphilic, meaning it contains both water-attracting and water-repelling regions