Its products are S-formylglutathione, reduced NADH, and a proton
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Under conditions of mitochondrial stress, PINK1 accumulates on the outer mitochondrial membrane, recruiting Parkin, which ubiquitinates mitochondrial proteins (Fig
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This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 192,54 per year only 16,05 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Holst, J
In human studies, Nrf2 suppression has been linked to cataract formation in lenses collected from diabetic and older patients, with the upregulation of Keap1 (an Nrf2 suppressor) found in these individuals