Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)
On GLP-1s, appetite changes can influence how much food feels comfortable at each meal
Gasiorek A, Heydorn A, Gabery S et al (2025) Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial
Since GLP-1 medications slow how fast food leaves your stomach, large meals can feel heavy and cause bloating
Overall agreement 80%: A+ 55%, A 25%, A 20%, D 0%, D 0%, D+ 0%
When underwriters exercised their overallotment option in full on 20 April, the final gross proceeds reached $718.8 million