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Researchers also taking insulin If you use both insulin and a GLP-1 agonist, timing coordination matters
Other Potential Concerns Rare but serious adverse effects include pancreatitis (presenting as severe abdominal pain), gallbladder disease, and potential thyroid effects
doi: 10.1080/00325481.2015.993276 98 GongNXiaoQZhuBZhangCYWangYCFanHet al
The addition of DPP-4 inhibitors to patients already treated with metformin may seem particularly attractive, since both drugs may act to enhance circulating levels of GLP-1 and thus, may have synergistic effects on incretin receptor signaling [44,45,46]
The compound is stable at pH 5.5-7.0 and should not be mixed with chelating agents (EDTA) that would strip the copper ion
It may also protect cardiovascular cells from damage by inhibiting cell death processes such as apoptosis and necrosis
