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Of these, 47 participants in the semaglutide group and 46 participants in the placebo group completed the study

Patients who received GLP-1 RAs were younger (mean 58.7 vs 67.1 years), had higher BMI (mean 37.8 vs 33.3), and were more often female (70.6% vs 52.1%) compared with those who did not receive these medications

Researchers should design protocols with appropriate monitoring, ethical oversight, and realistic safety endpoints

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It is relevant for studies involving GLP-1 signaling, insulin-related pathways, appetite regulation, and gastric emptying research

Cell Rep (2016) 14(9):214253.10.1016/j.celrep.2016.02.013 180 El KaoutariAArmougomFGordonJIRaoultDHenrissatB