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For intramuscular injection, stretch the skin taut and insert the needle at 90 degrees into the muscle

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While B vitamins are water-soluble and are generally excreted in the urine when in excess, extremely large and repeated doses can overwhelm the body's ability to eliminate them efficiently

Without this offset, both compounds compete for limited NAD+ and receptor access simultaneously, creating a metabolic bottleneck that reduces efficacy of both

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