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Paik S, Kim JK, Silwal P, Sasakawa C, Jo EK
GLP-1 medications like semaglutide work
Under normal circumstances, insulin maintains the NAD(+)/NADH ratio by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway and inhibiting the forkhead box protein O1/heme oxygenase 1 (Foxo1/Hmox1) pathway, thereby mediating the activation of the sirtuin 1/peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (SIRT1/PGC-1) pathway and regulating mitochondrial physiological functions (27)
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Lane WS, Weatherall J, Gundgaard J, Pollock RF
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