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They then performed 1:1 propensity score matching to create clinically comparable groups in three key analyses
Two vials can look identical, contain the same amount of liquid, yet deliver completely different doses because one solution is more concentrated than the other
Doi:10.1046/j.1523-1747.1999.00708.x Ionescu M, Frohman LA
Semaglutide and tirzepatide are the most common
Side Effects Semaglutide: Common Side Effects: Nausea Vomiting Diarrhoea Constipation Abdominal pain Less Common Side Effects: Headache Fatigue Dizziness Hypoglycaemia (especially in individuals with type 2 diabetes) Pancreatitis (rare but serious) Tirzepatide: Common Side Effects: Nausea Vomiting Diarrhea Constipation Abdominal pain Less Common Side Effects: Decreased appetite Dyspepsia (indigestion) Injection site reactions Hypoglycemia (more common when combined with insulin or sulfonylureas) Pancreatitis (rare but serious) Administration Semaglutide: Administered via injection
Yet behind the overnight success of GLP-1 therapeutics lies decades of taxpayer-funded research
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