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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66
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Oxygen radicals such as superoxide anion (O2) and singlet oxygen, (1O2) are easily generated from the sequential reduction of molecular oxygen via step-wise addition of electrons
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