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Advanced Type 2 diabetes with severe beta cell dysfunction: Patients who have had diabetes for decades with minimal remaining insulin production may see less glucose benefit (though weight loss still occurs)

doi: 10.1056/nejmoa2032183

THERAPEUTIC INTERVENTIONS CLINICAL EXAMPLES AND THERAPEUTIC FORMS: N-acetylcysteine (NAC) Improving cellular glutathione status remains a clinical challenge, though interventions which enhance glutathione synthesis have for the most part been successful, most notably N-acetylcysteine (NAC)

For additional blood sugar control, you can increase your dose by 2.5 mg after at least 4 weeks on the current doseup to a maximum of 15 mg once a week

Thomas R, Irene G, Tim K, Yuliang W, Michael S, David T

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