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We have previously shown that, in the region surrounding the NPEY motif, 4 out of 16 residues differ between the IR and IGF1R (equivalent to Pro963, Ser968, Leu973, and Ser976 in the IR) and by systematic substitution of each of these residues showed that only replacement of leucine-973, the residue in the +1 position following the NPEY motif, with phenylalanine results in a shift from binding IRS-1 to binding Shc in a receptor pull-down assay (14)

Two clinical trials evaluated EPA only at doses of 1.8 and 4 grams (the 4-gram trial used icosapent ethyl, a specific form of EPA used in the FDA-approved drug Vascepa)

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

In addition, it has anti-inflammatory properties

We acknowledge Jawaharlal Nehru University, New Delhi for providing financial assisatnce towards publication

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