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Ukleja A, Romano MM
& Reisen, W
In addition, in OA chondrocytes, the decrease in the activity of respiratory chain complexes I, II and III may affect several pathways related to cartilage degradation, including oxidative stress, biosynthesis of chondrocytes, increased inflammation and matrix catabolism induced by cytokines, calcification of cartilage matrix and increased apoptosis of cartilage cells (Blanco et al., 2011)
The authors of a 2022 review described the relationship as a vicious cycle: melatonin synthesis decreases as you grow older, and the aging process worsens because of melatonin deficiency
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