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The development of melanocytes from neural crest cells, as well as their ability to migrate, is dependent upon interactions between specific receptors and extracellular ligands, including endothelin 3 and the endothelin B receptors, melanocyte stimulating hormone and the melanocortin-1 receptor stem cell factor and its receptor KIT, each of which induce expression of the microphthalmia-associated transcription factor (MITF)
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The GIP receptor activation may specifically influence how the body handles fat storage and mobilization, providing a metabolic advantage beyond simple caloric restriction
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