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J., Akerstrom, V
Melanin macroglobules (large pigment particles resulting from fusion of autophagosomes containing varying numbers of melanosomes) may be found in CALMs, but they are not specific for neurofibromatosis, as they are occasionally found in isolated CALMs (without any underlying disease) and occur in several other conditions such as simple lentigines, Becker melanosis, congenital melanocytic nevi, and sometimes even normal skin
Circulation (2013) 127(1):7485
Most patients come in for weekly or biweekly check-ins, where progress is evaluated and dosage adjustments are made if needed
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A number of studies have also validated the therapeutic potential of sommarutide in NASH [113,120,121]
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